Targeted Therapy for Brain Cancer
Targeted therapies for brain cancer work to target specific pathways or abnormalities in brain tumor cells involved in tumor growth. We will likely combine targeted therapy with other brain cancer treatments, such as chemotherapy. This treatment is often an option for brain cancer patients who have a tumor recurrence after previous brain cancer treatments.
One targeted therapy used to treat brain tumors is the drug bevacizumab (Avastin®), which is given intravenously. This monoclonal antibody therapy works to stop the formation of new blood vessels that a brain tumor needs to grow, a process known as angiogenesis.
Managing the side effects of targeted therapy
Targeted drug therapy can cause side effects, such as low blood counts, tiredness, mouth sores, nausea, diarrhea, high blood pressure and fluid buildup (usually in the legs).
Throughout your brain cancer treatment, your care team provides various integrative oncology services, like nutrition therapy, naturopathic medicine, mind-body medicine and oncology rehabilitation, to keep you strong, reduce side effects and improve your quality of your life.
What is targeted therapy?
Targeted therapies are drugs or other substances designed to block the growth and spread of cancer by preventing cancer cells from dividing or by destroying them directly. While standard chemotherapy affects all cells in the body, targeted therapy directs drugs or other specially created substances (e.g., immune system proteins developed in the lab) to attack cancer cells. The goal of targeted therapy is to interfere with genes or proteins involved in tumor growth to block the spread of the disease.
By targeting specific molecules that are responsible for the growth, progression and spread of cancer, targeted therapy differs from standard chemotherapy, which attacks the disease systemically and, therefore, also damages healthy cells. Because targeted therapy specifically seeks out cancer cells, it is designed to reduce the harm to healthy cells, which may lead to fewer side effects than standard chemotherapy.
Targeted therapies serve as the foundation of precision medicine, which uses information about a tumor’s DNA profile to identify additional treatment options. Tailored treatments target abnormalities that may be found in each tumor’s DNA profile. This innovation marks a shift from traditional treatments designed for the average patient, toward more precise therapies.
Targeted therapy is an evolving science, and not all cancer types may be treated with targeted drugs. Several targeted therapies have been approved by the U.S. Food and Drug Administration for use in cancer treatment, including hormone therapies, signal transduction inhibitors, apoptosis inducers, gene expression modulators, angiogenesis inhibitors and toxin delivery molecules.
To help identify an appropriate targeted therapy for your cancer, your doctor may order tests to learn more about the genetic disposition, protein composition and other factors the tumor exhibits. Patients may be a candidate for targeted therapy if the cancer did not respond to other therapies, has spread, is inoperable or meets other criteria. Targeted therapy may also be combined with surgery, chemotherapy, radiation therapy or hormone therapy.
Targeted therapy may be prescribed as oral pills, administered intravenously or delivered in other ways. Targeted therapy drugs may be administered in the hospital, or prescribed in pill form and taken at home. The treatment schedule is specific to each person and his or her cancer.