Colorectal Cancer – Cause and Risk Factors
Colorectal Cancer – Cause and Risk Factors, How does colorectal cancer develop?
Colorectal Cancer – Cause and Risk Factors, The causes for the development of colorectal cancer have not yet been completely clarified. However, it is now known that in principle several causes are responsible. These lead to an increase in the proliferation of the cells in the intestinal mucosa beyond the normal range. If the growth of the cells is completely out of control, cancer develops.
The transformation of healthy intestinal cells into cancer cells often occurs via benign precursors, the so-called intestinal polyps ( adenomas ). These are mushroom-like protuberances of the intestinal mucosa, which grow into the intestine. About 90 percent of colorectal cancer is caused by the fact that these polyps degenerate, their cells are transformed into cancer cells.
In rare cases, a change in the genotype is already present at birth. Then colorectal cancer is very common in the family. It is estimated that a total of about 10 to 15 percent of all colorectal cancer can be attributed to hereditary pre-stress.
In most cases, however, there is no single cause for cancer development. However, certain factors are known that increase the personal risk of colorectal cancer. Often there is a disposition. In addition, there are certain dietary and lifestyle habits. People with benign or inflammatory symptoms are also at risk.
An increased risk people,
- (Especially ulcerative colitis), especially if the disease has lasted for more than ten to fifteen years and affects a large part of the intestine.
- Who have or had close relatives with Darmpolypen.
- In the presence of familial adenomatous polyposis, (called FAP).
- In whose family colorectal cancer has already occurred, especially if the patients were younger than 50 years of age at the time of illness. The predisposition to this type of cancer can be inherited.
- Which are themselves or their close relatives with other types of cancer, for example, breast, ovarian or uterine cancer.
- Who suffer from Gardner syndrome.
- Who are suffering from the Peutz-Jeghers syndrome.
- Who suffer from HNPCC (Lynch syndrome).
- With unfavorable dietary habits, such as fat-rich and low-fiber diet. Also discussed are highly saline, cured or smoked as a possible trigger for colorectal cancer.
- With overweight and lack of exercise and nicotine .